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apalutamide will minimize the level or effect of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a solid CYP2C19 inducer, with medication which are CYP2C19 substrates can result in decreased publicity to those medicines.Adjunct use, if apprehension, nervousness or acute tensio